In the fall of 1998, John, Hope, Stefano, and Kristen all traveled to a jungle compound where they were introduced to Dr. Rolfe, the man working on the cure for Roman. Dr. Rolfe recognized Hope, but Stefano managed to warn him not to say anything to Hope. Hope ended up breaking into a storage room, which infuriated him because there were things, including a table, in that room that could jog her memory from the missing four years of her life. Stefano promptly locked the room up with a high tech lock. When Dr. Rolfe finally finished the cure, the vial containing the cure was dropped and it was lost. Dr. Rolfe and Stefano tell John and Hope that the only way to make another cure is for someone to brave the jungle and the natives and retrieve a special orchid. John and Hope volunteer to find the orchid. Hope and John found the orchid and John put it in his backpack, but a native knocked John off a cliff and Hope, Kristen, and Stefano thought he was killed. John's backpack was recovered, but the orchid was missing. Hope managed to find some of the orchid's seeds and Rolfe made a cure using them. Later, John returned to the compound, but was poisoned by a native's dart. Dr. Rolfe cured him as well and everyone left to go back to Salem.
Later, Peter showed up at the compound with Jungle Madness. Dr. Rolfe made Peter some pills, but Peter lost them when Peter attacked Rolfe and took off in his plane.